440+ Vacation Rentals & Holiday Homes in Seneca |
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  3. Anderson
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Seneca Accommodations - Hotels & Rentals

About Seneca Vacation Rentals

Discover More than 440 Incredible Getaway Rentals Available in Seneca. Choose from a Wide Selection of Villas, Hotels, and Other Rental Options. Explore Luxury Amenities at Affordable Prices, Creating the Ideal Base for Your Next Vacation. Plan Your Perfect Escape with Online Reservations and Uncover Fantastic Stays in Seneca.

Online Reservations Offers Numerous Last-Minute Deals on Villas, Hotels, and Rentals, Both Near You and Across the Globe. Whether You Need Accommodation for a Group or an Event, Be it a Hotel or Vacation Rental (Including Cabins and Private Luxury Villas), We're Here to Assist. With Online Reservations in Seneca, You Can Easily Compare Options from Multiple Suppliers with a Single Click to Find the Perfect Price Point, Amenities, and Style of Stay That Suit Your Needs. Looking for Group Deals, Properties with Private Pools, Hot Tubs, Pet-Friendly Options, or Spacious Master Suite Bedrooms with Open-Air Showers? You Can Find It All in the Online Reservations Vacation Rentals, Resorts, and Airbnb-Style Properties in Seneca. The Average Size of Places to Stay Near Seneca is 1589.25 ft², with Prices Averaging US $516 per Night.

Let Online Reservations Help You Discover the Ideal Holiday Rental to Create Lifelong Travel Memories in Seneca. Our Listed Prices Are Often Discounted Compared to Rack Rates. Simply Search for Your Destination and Secure the Perfect Place to Stay Today.

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Top Hotels & Vacation Rentals in Seneca

Type Count
Vacation Homes 326
Holiday Apartments 25
Cottages 16
Villas 1

Use these Quick Filters to Find a Vacation Rental in Seneca

★ Pro Tip: Online Reservations is a vacation rental website specializing in cottages, lake houses, and exclusive summer home rentals. We curate a vast selection of incredible properties from trusted suppliers, allowing you to compare prices and locations to find the perfect fit for your getaway. Create lasting memories in Seneca with Online Reservations.

Weather in Seneca, SC

View the weather forecast for Seneca before booking your Seneca Vacation Rentals to confirm your best time to go.

December - February
High 60°F       Low 26°F
March - May
High 77°F       Low 40°F
June - August
High 91°F       Low 64°F
September - November
High 84°F       Low 38°F

Activities SenecaGuest Reviews Local Attractions

A Large Selection of Hotels and Vacation Rentals from Around the World SenecaGuest Reviews Discover Exciting Activities and Must-Visit Destinations for Your Upcoming Journey


Keowee Reservoir
Clemson University
Lake Jocassee
Chattahoochee National Forest
Tallulah Gorge State Park
Anderson University
Toccoa Falls
Table Rock State Park
Lake Keowee
Lake Hartwell State Park
Memorial Stadium
Toccoa Falls College
Devils Fork State Park
Lake Hartwell
Anderson Mall
Oconee State Park
NewSpring Church
Southern Wesleyan University
Hartwell Dam
Keowee Key

Find Hotels & Vacation Rentals in these Cities and Neighborhoods


Pine Ridge Point 247 Properties
Emerald Pointe 192 Properties
Moorings of Keowee 183 Properties
Indian Oaks 173 Properties
Normandy Shores 164 Properties
Serenity Bay 160 Properties
Shelter Cove 155 Properties
Northlake Estates 154 Properties
Keowee 145 Properties
Newry 114 Properties
Utica 100 Properties
Saxony Forest 33 Properties

Frequently Asked Questions About Seneca?

What are the top hotels, lake houses & vacation rentals in Seneca?

We provide an array of great vacation destinations in Seneca. If you are looking to stay in or around the Seneca area, make sure to browse our options to find a premium rental location in a top vacation destination. Whether it is a few nights, a week, or more, we've got the luxury stays that rank among the Top Vacation Rentals in Seneca:

How many Hotels & Vacation Rentals have private pools in Seneca?

We have 4 Hotels & Vacation Rentals featuring a private pool in and near Seneca. Some of the best destinations to stay that feature or have access to a swimming pool are:

Which hotel, lake house, or vacation rental in Seneca is best for families?

Searching for a family-friendly getaway in Seneca? We've got you covered. Check out one of these luxurious getaways that are highly-rated and perfect fits for families of all sizes.

How many hotels, resorts, or rentals are available in Seneca?

Online Reservations™ offers a consistent supply of new options, combined with established great stays in top areas. Currently, the number of properties listed by Online Reservations™ in 2025 is over 440 in the Seneca area, and that number rises every day. By combining listings from multiple websites and travel providers, Online Reservations™ can provide you with a diverse amount of choices of the best luxury stays in Seneca.

Nearby Neighborhood (7) 
Neighborhood Property Count
Serenity Bay Vacation Rentals in Anderson, South Carolina 160
Indian Oaks Vacation Rentals in Anderson, South Carolina 173
Pine Ridge Point Vacation Rentals in Anderson, South Carolina 247
Emerald Pointe Vacation Rentals in Anderson, South Carolina 192
Moorings of Keowee Vacation Rentals in Anderson, South Carolina 183
Shelter Cove Vacation Rentals in Anderson, South Carolina 155
Keowee Plantation Vacation Rentals in Anderson, South Carolina 143

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